解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Zika virus (ZIVK) represents a new threat to global health, with particular relevance to neuroscientists, due to associated newborn and adult neurological disease. Consequences of vertical infection include microcephaly with brain and eye anomalies, and consequences of adult infection include Guillain-Barré syndrome (...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2016.11.031
更新日期:2016-12-07 00:00:00
abstract::Little is known about how animals integrate multiple sensory inputs in natural environments to balance avoidance of danger with approach to things of value. Furthermore, the mechanistic link between internal physiological state and threat-reward decision making remains poorly understood. Here we confronted C. elegans ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.10.030
更新日期:2016-12-07 00:00:00
abstract::Sensory experience evokes long-lasting changes in neural circuits through activity-dependent gene expression. Ataman et al. (2016) report in Nature that primates evolved novel transcriptional responses to neuronal activity, including induction of musclin/osteocrin (OSTN), which may regulate specialized aspects of prim...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.11.024
更新日期:2016-11-23 00:00:00
abstract::Glial cells respond to neuronal activation and release neuroactive molecules (termed "gliotransmitters") that can affect synaptic activity and modulate plasticity. In this study, we used molecular genetic tools, ultra-structural microscopy, and electrophysiology to assess the role of brain-derived neurotrophic factor ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.09.031
更新日期:2016-11-23 00:00:00
abstract::We developed a technology (capturing activated neuronal ensembles [CANE]) to label, manipulate, and transsynaptically trace neural circuits that are transiently activated in behavioral contexts with high efficiency and temporal precision. CANE consists of a knockin mouse and engineered viruses designed to specifically...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.10.015
更新日期:2016-11-23 00:00:00
abstract::A proposal for an Australian Brain Initiative (ABI) is under development by members of the Australian Brain Alliance. Here we discuss the goals of the ABI, its areas of research focus, its context in the Australian research setting, and its necessity for ensuring continued success for Australian brain research. ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.10.038
更新日期:2016-11-02 00:00:00
abstract::The brain has often been described, quite accurately, as one of the most complex objects in the natural world. Understanding its workings, to say nothing about intervening in them, is among the hardest problems in science. While this makes the challenge all the more enticing, in the short term, it acts to limit the im...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.10.044
更新日期:2016-11-02 00:00:00
abstract::In this issue of Neuron, Orbán et al. (2016) test whether the brain represents probabilities by sampling: do neurons interpret the world by generating causal explanations of sense data and quickly sample different interpretations over time? Orbán et al. (2016) find agreement between this model's predictions and neural...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.10.007
更新日期:2016-10-19 00:00:00
abstract::Identifying the spatial organization of tissues at cellular resolution from single-cell gene expression profiles is essential to understanding biological systems. Using an in situ 3D multiplexed imaging method, seqFISH, we identify unique transcriptional states by quantifying and clustering up to 249 genes in 16,958 c...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.10.001
更新日期:2016-10-19 00:00:00
abstract::Neocortical excitatory and inhibitory neurons derive from distinct progenitor domains during embryonic development and migrate to their final positions, where they assemble into functional circuits. This process appears to be influenced by lineage relationships among locally born excitatory neurons, raising the intrig...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.09.034
更新日期:2016-10-05 00:00:00
abstract::The embryonic basal ganglia generates multiple projection neurons and interneuron subtypes from distinct progenitor domains. Combinatorial interactions of transcription factors and chromatin are thought to regulate gene expression. In the medial ganglionic eminence, the NKX2-1 transcription factor controls regional id...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.08.020
更新日期:2016-09-21 00:00:00
abstract::Inhibition of granule cells plays a key role in gating the flow of signals into the cerebellum, and it is thought that Golgi cells are the only interneurons that inhibit granule cells. Here we show that Purkinje cells, the sole output neurons of the cerebellar cortex, also directly inhibit granule cells via their axon...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.08.011
更新日期:2016-09-21 00:00:00
abstract::Mutations in a synaptic organizing pathway contribute to autism. Autism-associated mutations in MDGA2 (MAM domain containing glycosylphosphatidylinositol anchor 2) are thought to reduce excitatory/inhibitory transmission. However, we show that mutation of Mdga2 elevates excitatory transmission, and that MDGA2 blocks n...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.08.016
更新日期:2016-09-07 00:00:00
abstract::The primary visual cortex has a map of multiple visual parameters whose topographic relations remain poorly understood. A new study (Nauhaus et al., 2016) reveals a nearly geometric map-topography that coexists within a remarkably precise representation of visual space. ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.08.001
更新日期:2016-08-17 00:00:00
abstract::Grid cells in medial entorhinal cortex (MEC) can be modeled using oscillatory interference or attractor dynamic mechanisms that perform path integration, a computation requiring information about running direction and speed. The two classes of computational models often use either an oscillatory frequency or a firing ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.06.027
更新日期:2016-08-03 00:00:00
abstract::The immediate early gene Arc (also Arg3.1) produces rapid changes in synaptic properties that are linked to de novo translation. Here we develop a novel translation reporter that exploits the rapid maturation and "flash" kinetics of Gaussia luciferase (Gluc) to visualize Arc translation. Following glutamate stimulatio...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.06.017
更新日期:2016-08-03 00:00:00
abstract::Cholinergic interneurons (CHIs) play a major role in motor and learning functions of the striatum. As acetylcholine does not directly evoke postsynaptic events at most striatal synapses, it remains unclear how postsynaptic cholinergic receptors encode the firing patterns of CHIs in the striatum. To examine the dynamic...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.06.021
更新日期:2016-08-03 00:00:00
abstract::Recent advances in connectomics have led to a synthesis of perspectives regarding the brain's functional organization that reconciles classical concepts of localized specialization with an appreciation for properties that emerge from interactions across distributed functional networks. This provides a more comprehensi...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2016.07.031
更新日期:2016-08-03 00:00:00
abstract::Telling time and anticipating when external events will happen is among the most important tasks the brain performs. Yet the neural mechanisms underlying timing remain elusive. One theory proposes that timing is a general and intrinsic computation of cortical circuits. We tested this hypothesis using electrical and op...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.05.042
更新日期:2016-07-20 00:00:00
abstract::In this issue of Neuron, Fossati et al. (2016) report that through its domain structure, SRGAP2A, a Rho-GTPase-activating protein, can co-regulate excitatory and inhibitory synapse development, offering a putative evolutionary genetic mechanism for preserving excitatory/inhibitory balance during speciation. ...
journal_title:Neuron
pub_type: 评论,杂志文章,评审
doi:10.1016/j.neuron.2016.07.008
更新日期:2016-07-20 00:00:00
abstract::To survive, humans must estimate their own ability and the abilities of others. We found that, although people estimated their abilities on the basis of their own performance in a rational manner, their estimates of themselves were partly merged with the performance of others. Reciprocally, their ability estimates for...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.06.022
更新日期:2016-07-20 00:00:00
abstract::Altered microRNA profiles have been implicated in human brain disorders. However, the functional contribution of individual microRNAs to neuronal development and function is largely unknown. Here, we report biological functions for miR-19 in adult neurogenesis. We determined that miR-19 is enriched in neural progenito...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.05.034
更新日期:2016-07-06 00:00:00
abstract::The study of patients with brain lesions has made major historical contributions to cognitive neuroscience. Here I argue for an increased investment in modern lesion mapping, complementing fMRI studies and laying the conceptual and analytic foundations for future techniques that could experimentally manipulate human b...
journal_title:Neuron
pub_type: 历史文章,杂志文章
doi:10.1016/j.neuron.2016.05.014
更新日期:2016-06-15 00:00:00
abstract::Long non-coding RNAs (lncRNAs) are a diverse and poorly conserved category of transcripts that have expanded greatly in primates, particularly in the brain. We identified an lncRNA, which has acquired 16 microRNA response elements for miR-143-3p in the Catarrhini branch of primates. This lncRNA, termed LncND (neurodev...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.05.005
更新日期:2016-06-15 00:00:00
abstract::Effective error-driven learning benefits from scaling of prediction errors to reward variability. Such behavioral adaptation may be facilitated by neurons coding prediction errors relative to the standard deviation (SD) of reward distributions. To investigate this hypothesis, we required participants to predict the ma...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.04.019
更新日期:2016-06-01 00:00:00
abstract::In Drosophila, negatively reinforcing dopaminergic neurons also provide the inhibitory control of satiety over appetitive memory expression. Here we show that aversive learning causes a persistent depression of the conditioned odor drive to two downstream feed-forward inhibitory GABAergic interneurons of the mushroom ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.04.034
更新日期:2016-06-01 00:00:00
abstract::The function of the CB2 cannabinoid receptor in the brain has long been a matter of debate. In this issue of Neuron, Stempel et al. (2016) describe a mechanism whereby endocannabinoid production leads to a cell-intrinsic hyperpolarization that controls self activity. ...
journal_title:Neuron
pub_type: 评论,杂志文章,评审
doi:10.1016/j.neuron.2016.05.012
更新日期:2016-05-18 00:00:00
abstract::Human confidence judgments are thought to originate from metacognitive processes that provide a subjective assessment about one's beliefs. Alternatively, confidence is framed in mathematics as an objective statistical quantity: the probability that a chosen hypothesis is correct. Despite similar terminology, it remain...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.03.025
更新日期:2016-05-04 00:00:00
abstract::The mechanisms that constrain memory formation are of special interest because they provide insights into the brain's memory management systems and potential avenues for correcting cognitive disorders. RNAi knockdown in the Drosophila mushroom body neurons (MBn) of a newly discovered memory suppressor gene, Solute Car...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.03.017
更新日期:2016-05-04 00:00:00
abstract::Properly functional CNS circuits depend on inhibitory interneurons that in turn rely upon activity-dependent gene expression for morphological development, connectivity, and excitatory-inhibitory coordination. Despite its importance, excitation-transcription coupling in inhibitory interneurons is poorly understood. We...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.03.001
更新日期:2016-04-20 00:00:00
abstract::By using a tau construct with two mimicked acetylation sites as identified in AD brains, Tracy et al. (2016) found that acetylated tau promotes synaptic dysfunction through disruption of postsynaptic KIBRA signaling pathways, actin dynamics, and AMPA receptor trafficking. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2016.04.008
更新日期:2016-04-20 00:00:00
abstract::We recently reported that homozygous Presenilin-1 (Psen1) knockin (KI) mice carrying the familial Alzheimer's disease (FAD) mutation L435F or C410Y recapitulate the phenotypes of Psen1(-/-) mice. Production and steady-state levels of Aβ40 and Aβ42 are undetectable in KI/KI brains and reduced in KI/+ brains, though the...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2016.03.009
更新日期:2016-04-20 00:00:00
abstract::In daylight, the input to the retinal circuit is provided primarily by cone photoreceptors acting as band-pass filters, but the retinal output also contains neuronal populations transmitting sustained signals. Using in vivo imaging of genetically encoded calcium reporters, we investigated the circuits that generate th...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.03.015
更新日期:2016-04-20 00:00:00
abstract::Loss of maternal UBE3A causes Angelman syndrome (AS), a neurodevelopmental disorder associated with severe epilepsy. We previously implicated GABAergic deficits onto layer (L) 2/3 pyramidal neurons in the pathogenesis of neocortical hyperexcitability, and perhaps epilepsy, in AS model mice. Here we investigate consequ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.02.040
更新日期:2016-04-06 00:00:00
abstract::Interactions between the hippocampus and prefrontal cortex (PFC) are critical for learning and memory. Hippocampal activity during awake sharp-wave ripple (SWR) events is important for spatial learning, and hippocampal SWR activity often represents past or potential future experiences. Whether or how this reactivation...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.02.010
更新日期:2016-04-06 00:00:00
abstract::Using somatic cell nuclear transfer, Hazen et al. (2016) examined clonally expanded single neurons for mutations and found ∼100 mutations from a variety of classes. Post-mitotic mutations in individual neurons represent an exploratory direction for finding fundamental origins of neurodegeneration. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2016.02.042
更新日期:2016-03-16 00:00:00
abstract::Piezo proteins have been proposed as the long-sought-after mechanosensitive cation channels in mammals that play critical roles in various mechanotransduction processes. However, the molecular bases that underlie their ion permeation and mechanotransduction have remained functionally undefined. Here we report our find...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.01.046
更新日期:2016-03-16 00:00:00
abstract::SCA1, a fatal neurodegenerative disorder, is caused by a CAG expansion encoding a polyglutamine stretch in the protein ATXN1. We used RNA sequencing to profile cerebellar gene expression in Pcp2-ATXN1[82Q] mice with ataxia and progressive pathology and Pcp2-ATXN1[30Q]D776 animals having ataxia in absence of Purkinje c...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.02.011
更新日期:2016-03-16 00:00:00
abstract::Huntingtin (HTT) is now a famous protein because an abnormal expansion of a glutamine stretch (polyQ) in its N-terminal sequence leads to the devastating neurodegenerative disorder Huntington's disease (HD). The gene encoding huntingtin, HTT, and its dominantly inherited mutation were identified more than 20 years ago...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2016.02.003
更新日期:2016-03-02 00:00:00
abstract::Neuronal circuit function is governed by precise patterns of connectivity between specialized groups of neurons. The diversity of GABAergic interneurons is a hallmark of cortical circuits, yet little is known about their targeting to individual postsynaptic dendrites. We examined synaptic connectivity between molecula...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.01.029
更新日期:2016-03-02 00:00:00